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Piazza G.Puccini, 26
50144 Firenze, Italy
+39 055 354829


A complete navigation platform for lower limb surgery

The only open source platform available on the market.

With BLU-IGS you are not linked to a specific implant model. This allows the surgeons to freely choose their desired prosthesis and technics.


Our navigation system is focused on the surgeons’ experience.

Easy to use

Open platform




For Companies

For Surgeons

BLU-IGS covers the major interventions

of the lower limb prosthetics.

Total Knee Arthroplasty
Uni-compartmental Knee Arthroplasty
Revision of Total Knee Arthroplasty
Total Hip Arthroplasty
High Tibial Osteotomy
Lower limb intra-operative kinematics evaluation


Clinical Evidences


“ Trochelar groove is a reliable intraoperative landmark during navigated TKA”

Grassi A, Asmonti I, Bignozzi et al.


“The restoration of healthy knee kinematics, notably femoral rollback and physiologic tibial rotation, is particularly important in TKA[...] Navigated comparisons of navigated kinematics between native knees and implanted knees show similar patterns of physiologic femoral rollback.”

Zaffagnini S, Bignozzi S, Saffarini M, et al.


“Our system clearly shows that the use of navigation systems for kinematic evaluation provides useful and complete information on the knee state and test performance, and is simple and reliable to use.”

Martelli S, Zaffagnini S, Bignozzi S, Lopomo N, Marcacci M.


“Using our navigation system to study hip joint kinematics, removal of skin and muscle did increase hip ROM, nearly equally in all planes.”

Safran MR, Lopomo N, Zaffagnini S, et al.


"A computer-assisted surgical technique for RTKA was presented. During planning phase it allows the surgeon to analyse the consequences of each decision he takes, including the opportunity to check different implant solutions."

Marcacci M, Nofrini L, Iacono F, Martino A Di, Bignozzi S.

Grassi A, Asmonti I, Bignozzi et al. The sagittal geometry of the trochlear groove could be described as a circle: an intraoperative assessment with navigation. Knee Surg Sports Traumatol Arthrosc. 2021 Jun;29(6):1769-1776. doi: 10.1007/s00167-020-06224-w. Epub 2020 Aug 12. PMID: 32785759


Zaffagnini S, Bignozzi S, Saffarini M, et al. Comparison of stability and kinematics of the natural knee versus a PS TKA with a 'third condyle'. Knee Surg Sports Traumatol Arthrosc. 2014 Aug;22(8):1778-85. doi: 10.1007/s00167-014-3016-3. Epub 2014 May 6. PMID: 24797810.


Martelli S, Zaffagnini S, Bignozzi S, Lopomo N, Marcacci M. Description and validation of a navigation system for intra-operative  evaluation of knee laxity. Comput Aided Surg. 2007 May;12(3):181-8. doi: 10.3109/10929080701387259. PMID:17538791.

Safran MR, Lopomo N, Zaffagnini S, et al. In vitro analysis of peri-articular soft tissues passive constraining effect on hip kinematics and joint stability. 2012. doi:10.1007/s00167-012-2091-6


Momi E De, Lopomo N, Cerveri P, Zaffagnini S, Safran MR, Ferrigno G. In-vitro experimental assessment of a new robust algorithm for hip joint centre estimation. 2009;42:989-995. doi:10.1016/j.jbiomech.2009.02.031


Marcacci M, Nofrini L, Iacono F, Martino A Di, Bignozzi S. A novel computer assisted surgical technique for revision total knee arthroplasty. 2007;37:1771-1779. doi:10.1016/j.compbiomed.2007.05.004


Lopomo N, Zaffagnini S, Bignozzi S, Visani A, Marcacci M. Pivot-Shift Test: Analysis and Quantification of Knee Laxity Parameters Using a Navigation System. 2010;(January 2009):164-169. doi:10.1002/jor.20966


Lopomo N, Sun L, Zaffagnini S, Giordano G, Safran MR. Evaluation of formal methods in hip joint center assessment: An in vitro analysis. Clin Biomech. 2010;25(3):206-212. doi:10.1016/j.clinbiomech.2009.11.008


Colle F, Bignozzi S, Lopomo N, Zaffagnini S, Sun L, Marcacci M. Knee functional flexion axis in osteoarthritic patients : comparison in vivo with transepicondylar axis using a navigation system. 2012:552-558. doi:10.1007/s00167-011-1604-z


Casino D, Zaffagnini S, Martelli S, et al. Intraoperative evaluation of total knee replacement: kinematic assessment with a navigation system. 2009:369-373. doi:10.1007/s00167-008-0699-3


Bignozzi S, Zaffagnini S, Iacono F, Marcacci M. Does a lateral plasty control coupled translation during antero-posterior stress in single-bundle ACL reconstruction? An in vivo study. 2009:65-70. doi:10.1007/s00167-008-0651-6


Our key reference centers

What our customers say about us

"I must say that Orthokey left a lasting impression on me. From the warm welcome to the insightful demo, it was evident that Orthokey is dedicated to excellence and innovation in all aspects. Your commitment to delivering top-notch products and services is truly commendable."
Prof. Bernardo Innocenti
ULB Bruxelles
"I wanted to say a huge thank you for all your support, hospitality and kindness in our journey to get Orthokey Navigation into Australia. It is a true pleasure working with all of you."
Chris Papadopulos
MicroPort Australia
"Young company. With a strong attitude to listen to and interact with surgeons."
Dr. Dante Dallari
Istituto Rizzoli Bologna

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